Genotoxicity Assessment Unit
This Unit is capable of screening compounds for such properties as cytotoxicity and potential genotoxicity using validated in vitro test systems.
The current genetic toxicity testing programme has evolved from a broader initiative to identify methods for assessing DNA damage that can be used in large epidemiological studies. The Assays include: Single cell gel electrophoresis or Comet assay, 8-hydroxy-2-deoxyguanine and micronuclei assay. This unit also runs general oxidative stress assays such as lipid peroxidation, Nitric Oxide production, apoptosis, oxidative burst and inflammatory markers.